Endocrine Abstracts

Background: Craniopharyngiomas (CPs) are epithelial tumors that typically arise in the suprasellar region. They are associated with high levels of morbidity related to tumour location and/or treatment-related injuries. Recent discoveries have also led to a better understanding of CP development and potential treatments.Objetive: To analyse the clinical, pathological, molecular features and outcomes of patients with CP.Design: Retro...

Introduction: PCSK9 inhibitors (iPCSK9) have previously been evaluated through controlled clinical trials showing up to 60% reduction in LDL cholesterol concentrations. However, we still do not have enough data regarding the real life experience of the treatment.Objectives: 1) Describe patients with hypercholesterolemia treated with iPCSK9 in clinical practice.2) Evaluate treatment efficacy and safety.Methods...

Introduction: The immunohistochemical characterization of Pit-1, Tpit and SF-1 transcription factors allows the identification of the three adenohypophyseal cell lines and has been incorporated into the latest WHO classification of pituitary adenomas (PA). The aim of the present study was to quantify the protein expression of pituitary-specific transcription factors (TF) by immunohistochemistry (IHC) and to correlate these results with the identification based on hormonal prot...

Introduction: In recent years, numerous studies on the relationship between the TSH of the first trimester of pregnancy and obstetric complications have been published, and in this context it has been recommended to treat with levothyroxine from certain values of TSH. The aim of this study was to determine the incidence of obstetric and neonatal complications in pregnancies with normal TSH (0.14 to 2.49 mcU/ml) as a basis for assessing complications in pregnancies with TSH bet...

Introduction: Gonadotroph tumours (GT) are the most common subtype of silent pituitary neuroendocrine tumours. The diagnosis of this subtype of tumours is established after surgery. There are no reliable markers of aggressiveness to predict their clinical course and, moreover, immunohistochemistry (IHC) usually classifies GT as null cell tumours. The aim of the present study was to correlate molecular, immunohistochemical and biochemical gonadotropin expression, to quantify th...

IntroductionAlthough surgical treatment of acromegaly is the treatment of choice in most patients, a wide therapeutic arsenal is available. Medical treatment can be indicated as primary treatment, complementary and even as pre-operative treatment.ObjectivesTo determine the prevalence of uncured acromegaly and the prevalence of controlled disease within this group. To clinically, biochemically and histological...